EFFECTS OF POSITIVE AND EXPIRATORY PRESSURE AND COUNTERPRESSURIZATION ON CIRCULATING PROSTAGLANDINS IN THE DOG

Authors
  1. Sunahara, F.A.
  2. Sun, C.
  3. Harding, S.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN);Toronto Univ, Toronto ONT (CAN) Dept of Pharmacology
Abstract
The effects of the application of positive and expiratory pressure (PEEP) ventilation, with and without body counterpressure (CP), on circulating prostaglandin-like substances (PGL) were studied in chloralose anesthetized dogs. The normal respiratory movements were paralysed with succinylcholine chloride. Arterial levels of PGL were continuously bioassayed using Vane's blood superfusion method. PEEP's of 10 and 20 mm Hg elicited PEEP-related increases in functional residual capacity and circulating PGL levels and decreases in blood pressure, left ventricular dP/dt, and heart rate. The PGL appeared to be PGE or prostacyclin in character. When PEEP and CP were simultaneously applied, the increments or decrements of indices described above were reduced. TRUNCATED
Report Number
84-P-06 — Research Paper
Date of publication
15 Jun 1984
Number of Pages
6
Reprinted from
Aviat Space Environ Med, vol 55, 1984, p 550-555
DSTKIM No
84-04466
CANDIS No
91284
Format(s):
Microfiche filmed at DSIS;Originator's fiche received by DSIS;Hardcopy

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