Search for Radioprotective Compounds. Part XVII. PROTECTION AFFORDED BY ADENOSINE NUCLEOTIDES ALONE AND IN COMBINATION WITH SOME OTHER RADIOPROTECTIVE AGENTS

Authors
  1. Grant, G.A.
  2. Barlow, J.A.
  3. Leach, K.E.
  4. Inayeh, K.E.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
Protection afforded by administration intraperitoneally to mice of adenosine nucleotides alone and in combination with other radioprotective agents was determined. Cyclic 3'-5'-adenosine monophosphate provided a dose reduction factor (DRF) of 1.43, while combinations of nucleotides afforded DRF values of up to 1.50. A combination of protective agents WR 2822, cysteamine and adenosine triphosphate (ATP) showed DRF values of 2.23. Evidence is presented that cAMP does not play a role in the mechanism of protection of thiol agents but may play a role in protection afforded by catecholamine. Evidence is also presented that the protection afforded by ATP may be due to its pharmacological action.
Report Number
750 —
Date of publication
15 Oct 1976
Number of Pages
38
DSTKIM No
76-04604
CANDIS No
93372
Format(s):
Hardcopy;Originator's fiche received by DSIS

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