Search for Radioprotective Compounds. Part XVI. ALPHA-BLOCKING AND RADIOPROTECTIVE ACTIVITY OF SOME ALIPHATIC SULPHUR-CONTAINING AMINES

Authors
  1. Grant, G.A.
  2. Leach, K.E.
  3. Belleau, B.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
A series of analogs of the disulfide, 1, 18-diamino-6, 13-diaza 9, 10-dithiaoctadiamine was prepared and tested for alpha-blocking and radioprotective activity. Some of the analogs were more active alpha-blocking agents than the parent compound. None of the compounds exhibited significant radioprotective activity. The thiol group in the alpha-receptor is not related to radioprotective activity. However, some of the radioprotective compounds, when injected into animals, may be metabolized and products may exhibit alpha-blocking and radioprotective activity. It was also noted that the addition of some chemical groups to a radioprotective or alpha-blocking agent decreased its activity indicating that there are very specific chemical structures at both active sites.
Report Number
751 —
Date of publication
15 Oct 1976
Number of Pages
18
DSTKIM No
76-04605
CANDIS No
93373
Format(s):
Hardcopy;Originator's fiche received by DSIS

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