EFFICACY OF HI-6 AGAINST SOMAN AND TABUN CHALLENGES IN PRIMATES AND RODENTS

Authors
  1. Hamilton, M.G.
  2. Lundy, P.M.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
The bis-pyridinium oxime, HI-6, in conjunction with atropine was found to offer significant protection against multiple LD sub 50 challenges with the organophosphorus compounds soman and tabun. In adult rhesus macaques, the therapeutic administration of 15 mg/kg (i.v.) or 50 mg/kg (i.m.) of HI-6 protected almost all of the animals from the lethal effects of 5 x LD sub 50 of either soman or tabun. In rats, the 24 hour protective ratio against tabun and soman was 2 and 3.5, respectively, whereas in guinea pigs these values were between 4 and 6 for both agents. No evidence was obtained for acehylcholinesterase (AchE) reactivation by HI-6 after injection of tabun in rodent tissue or after soman or tabun in primate plasma. The results demonstrate the significant therapeutic benefit of HI-6 in primates, a species specific efficacy against tabun, and argue for some mechanism for some mechanism of action of HI-6 at least partly unrelated to AchE reactivation.
Report Number
DRES-438 —
Date of publication
15 Oct 1986
Number of Pages
22
DSTKIM No
86-04559
CANDIS No
95431
Format(s):
Hardcopy;Originator's fiche received by DSIS

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