MOTION SICKNESS - PHYSIOLOGICAL EFFECTS AND PREVENTION

Authors
  1. Sunahara, F.A.
  2. Johnson, W.H.
Corporate Authors
Toronto Univ, Toronto ONT (CAN) Dept of Pharmacology;Toronto Univ, Toronto ONT (CAN) Dept of Otolaryngology;Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Symptoms of motion sickness (MS) were elicited in young healthy, volunteers. Arterial blood pressure (BP), heart rate (HR) and forearm blood flows (BF), by venous occluding plethysmography, were intermittently monitored every 30 s. rotation at 20 RPM and cyclic HM (nodding action) were continued until the subject requested cessation of HM because of imminent emesis or for 10 min. MS was elicited in approximately 70% of the subjects. There were no consistent changes in BP or HR but marked increases in BF were observed prior to or concomitant with symptoms of MS. There was an inverse correlation between duration of HM and increments in BF. Medication with antimotion sickness mixtures: scopolamine:d-amphetamine (0.4:5.0 mg) or promethazine:-ephedrine (25:60 mg) failed to significantly increase the duration of HM, the latter mixture, however, did significantly reduce the HM induced-hyperaemic responses.
Date of publication
15 Jan 1986
Number of Pages
47
DSTKIM No
86-04583
CANDIS No
95455
Format(s):
Hardcopy

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