PHYSICOCHEMICAL AND IMMUNOLOGICAL PROPERTIES OF ALBUMIN-ASSOCIATED DIALKYL-ETHER PHOSPHATIDYLCHOLINE LIPOSOMES

Authors
  1. Shek, P.N.
  2. Yung, B.Y.K.
  3. Stanacev, N.Z.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The efficacy of unilamellar and multilamellar dialkyl-ether phosphatidylcholine liposomes in eliciting antibody formation was examined. Mice were injected with liposome-entrapped bovine serum albumin and the albumin-specific plaque-forming cell response was evaluated. The unilamellar vesicles were found to be more effective than their multilamellar counterparts in promoting the elicitation of the anti-bovine serum albumin plaque-forming cell response. Within each category of lamellar structure, i.e., unilamellar or multilamellar bilayers, liposomes composed of dialkyl-ether phosphatidylcholines are less efficient than those of diacyl-ester phosphatidylcholines in potentiating the humoral immune response. TRUNCATED
Report Number
DCIEM-85-P-46 — Research Paper
Date of publication
15 Jul 1985
Number of Pages
8
Reprinted from
Biochimica et Biophysica Acta, no 855, 1986, p 33-40
DSTKIM No
86-01953
CANDIS No
96675
Format(s):
Hardcopy;Originator's fiche received by DSIS

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