PRECLINICAL STUDIES OF THE OXIME, HI-6, AN ELEMENT OF THE TREATMENT OF SOMAN POISONING. APPENDIX 13. THE PHARMACOKINETICS OF HI-6 IN THE RAT AND DOG

Authors
  1. Briggs, C.J.
  2. Simons, K.J.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Manitoba Univ, Winnipeg MAN (CAN) Faculty of Pharmacy
Abstract
The pharmacokinetics of HI-6 have been studied in the dog and the rat using one intravenous dose, a concentrated and a dilute intramuscular dose of 20 mg/kg. The concentrations of HI-6 were measured by a spectrophotometric method which was sufficiently sensitive and specific for all but rat urine samples. The half-life of HI-6 in dogs and rats is short, 48 and 66 min respectively. The intramuscular route of administration does not affect the extent of absorption when compared to the intravenous dose. Diluting the intramuscular dose has no effect on the rate or extent of absorption. Thus, a dose of HI-6 is rapidly and completely absorbed following intramuscular administration.
Report Number
CR-26/85 — Contract Report (Final), See also DRES-M-1031, Appendix 14, AD-A155-146 (DSIS 82-00408)
Date of publication
15 Mar 1982
Number of Pages
55
DSTKIM No
86-02004
CANDIS No
96724
Format(s):
Hardcopy

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