A STUDY OF POSSIBLE BIOCHEMICAL MECHANISMS INVOLVED IN HYPERBARIC OXYGEN-INDUCED CHANGES IN CEREBRAL GAMMA-AMINOBUTYRIC ACID LEVELS AND ACCOMPANYING SEIZURES

Authors
  1. Wood, J.D.
  2. Radomski, M.W.
  3. Watson, W.J.
Corporate Authors
Defence Research Establishment Toronto, Downsview ONT (CAN);Saskatchewan Univ, Saskatoon SASK (CAN) Dept of Biochemistry
Abstract
A linear correlation was obtained between the relative rate of a-aminobutyric acid (GABA) metabolism in chicks of different ages during a period of rapid brain development and the susceptibility of the birds to seizures induced by hyperbaric oxygen (O.H.P.). Since the changes taking place with age in the activities of the two enzymes involved in GABA metabolism (glutamic acid decarboxylase and GABA-o-ketoglutarate transaminase) were similar, the enzyme system primarily responsible for the O.H.P.- induced decreases in cerebral GABA levels and accompanying seizures could not be identified. Both enzyme systems may be involved. The possible involvement of an increased transport of GABA through cellular membranes in the production of low cerebral GABA levels could not be demonstrated in the present experiments.
Keywords
-aminobutyric acid
Report Number
RP-780 — Research Paper, Reprint 3385
Date of publication
01 Jan 1971
Number of Pages
5
Reprinted from
Canadian J of Biochemistry, vol 49, no 5, 1971, p543-547
DSTKIM No
71-04063
CANDIS No
9700
Format(s):
Hardcopy

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