HEAT PRODUCTION AFTER AMINOPHYLLINE ADMINISTRATION (AN ANIMAL MODEL STUDY)

Authors
  1. Wang, L.C.H.
Corporate Authors
Alberta Univ, Edmonton ALTA (CAN) Dept of Zoology;Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
A series of studies, using the Sprague-Dawley rat model, examined the effects of temperature acclimation, selective substrate availability, and chronic vs. acute treatment with aminophylline (AMP) on AMP-stimulated thermogenesis during cold exposure. It was concluded that AMP causes a net increase in substrate mobilization which induces a net increase in thermogenesis, regardless of acclimation temperature, which ranged from 5-25C. Neither lipid nor protein feeding enhanced thermogenesis more than aminophylline alone during cold exposure. In contrast, sucrose, in particular glucose, did potentiate the AMP-induced thermogenesis. These findings suggest that improving endogenous glucose supply through neuro-humoural means could be a useful strategy in potentiating aminophylline's thermogenic action.
Date of publication
15 Mar 1986
Number of Pages
66
DSTKIM No
86-02374
CANDIS No
97087
Format(s):
Hardcopy;Originator's fiche received by DSIS

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