MOTION SICKNESS - PHYSIOLOGICAL EFFECTS AND PREVENTION

Authors
  1. Sunahara, F.A.
  2. Johnson, W.H.
Corporate Authors
Toronto Univ, Toronto ONT (CAN) Dept of Pharmacology;Toronto Univ, Toronto ONT (CAN) Dept of Otolaryngology;Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Symptoms of motion sickness (MS) were elicited in young healthy volunteers. They were subjected to simultaneous rotation through the vertical axis and head movements (HM). Arterial blood pressure (BP), heart rate (HR) and forearm blood flows (BF), were intermittently monitored every 30 s. rotation at 20 RPM and cyclic HM (nodding action) were continued until the subject requested cessation of HM because of imminent emesis or for 10 min. There were no consistent changes in BP or HR but marked increases in BF were observed prior to or concomitant with symptoms of MS. There was an inverse correlation between duration of HM and increments in BF. Medication with antimotion sickness mixtures: scopolamine:d-amphetamine or promethazine:-ephedrine failed to significantly increase the duration of HM.
Date of publication
15 Jan 1986
Number of Pages
44
DSTKIM No
86-02377
CANDIS No
97090
Format(s):
Hardcopy;Originator's fiche received by DSIS

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