TRACE ANALYSIS OF MYCOTOXINS IN BLOOD BY CAPILLARY COLUMN-AMMONIA CHEMICAL IONIZATION MASS SPECTROMETRY

Authors
  1. D'Agostino, P.A.
  2. Provost, L.R.
  3. Drover, D.R.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN)
Abstract
Capillary column-ammonia chemical ionization mass spectrometry was found to be an excellent technique for the trace detection and identification of underivatized trichothecene mycotoxins in blood. Abundant (M + H)(+) and/or (M + NH4)(+) pseudo-molecular ions were observed for T-2 toxin, HT-2 toxin, T-2 triol, diacetoxyscirpenol, deoxynivalenol and verrucarol under the conditions suggested. Detection limits in the 0.7 to 5.1 ng/g range were possible due to the specificity of the method. The method was successfully applied to the analysis of blood samples spiked with an undisclosed number of mycotoxins during a recent interlaboratory exercise. T-2 toxin, HT-2 toxin, diacetoxyscirpenol and verrucarol were detected in these samples at levels ranging from 2 to 180 ng/g.
Report Number
DRES-427 —
Date of publication
15 Apr 1986
Number of Pages
49
DSTKIM No
86-02378
CANDIS No
97091
Format(s):
Hardcopy;Originator's fiche received by DSIS

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