STUDY OF THE EFFECTS OF EMETIC PEPTIDES ON INTESTINAL BLOODFLOW

Authors
  1. Buell, M.G.
Corporate Authors
Buell (M G), Ottawa ONT (CAN);Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
The gut-derived peptide PYY has recently been identified as a potent mediator of emesis in the dog. The study was designed to examine the effects of an emetic-dose of PYY on splanchnic bloodflow distribution, cardiovascular status and small intestinal motility in anaesthetized dogs. An infusion of 0.1 mu-g/kg/min of PYY, led to localized, significant reductions of bloodflow to the muscle wall in the jejunum and ileum. The time to onset of the changes in flow to specific tissues, and in the observed decrease in cardiovascular output were correlated to the time to onset of emesis in the conscious animal. Changes in force, but not frequency of intestinal contractions also correlated with changes in bloodflow in the jejunum and ileum. These results provide further support for the notion that PYY is a relevant emetic peptide and provide some insight into the mode of action of this candidate hormone.
Date of publication
15 Sep 1985
Number of Pages
51
DSTKIM No
86-02867
CANDIS No
97565
Format(s):
Hardcopy;Originator's fiche received by DSIS

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