DEXAMETHASONE: A POTENT BLOCKER FOR RADIATION-INDUCED TASTE AVERSION IN RATS

Authors
  1. Cairnie, A.B.
  2. Leach, K.E.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
Rats, trained to drink water during a single 30-min period each day, were then given 0.1% saccharin twice a week on other days for 30 min. If 20 rad of radiation (0.2 Gy) were given each time 30 to 40 min after the saccharin the rats developed a profound aversion to saccharin during the course of three weeks, whereas control groups failed to do so. This paradigm was then used to test the ability of drugs, given twice weekly immediatly after the saccharin, to prevent the development during three weeks of an aversion when 20 rad was given, 30 to 40 min later. Insulin, domperidone, haloperidol, acetylsalicylic acid, naloxone, chlorpheniramine, cimetidine, and dimethyl sulphoxide were tested without notable success. However dexamethasone, at doses ranging from 0.013 mg/kg to 1.3 mg/kg, significantly attenuated the conditioned taste aversion by up to 60 percent. TRUNCATED
Report Number
DREO-867 —
Date of publication
01 Jan 1982
Number of Pages
7
Reprinted from
Pharmacology Biochemistry and Behavior, vol 17, 1982, p 305-311
DSTKIM No
86-02915
CANDIS No
97611
Format(s):
Hardcopy;Originator's fiche received by DSIS

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