RADIOPROTECTION CONFERRED BY DEXTRAN SULFATE GIVEN BEFORE IRRADIATION IN MICE

Authors
  1. Ross, W.M.
  2. Peeke, J.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN);Ottawa Univ, Ottawa ONT (CAN) Dept of Physiology
Abstract
Dextran sulfate (DS) has been observed to cause mobilization (fivefold) of hemopoietic stem cells (HSC) and leukocytes, primarily lymphocytes, into the peripheral blood of mice within 2-3 h after intraperitoneal (i.p.) injection. This effect was dose dependent and was prolonged for several hours when the high-molecular-weight version DS500 (500,000 daltons) was used. When DS500 was given 1-3 days before irradiation, hemopoietic recovery was markedly enhanced. Postirradiation injection was ineffective. This study shows that dextran sulfate exerts a radioprotective influence on the hemopoietic system and hence survival when administered prophylactically.
Report Number
DREO-908 —
Date of publication
01 Jan 1986
Number of Pages
9
Reprinted from
Experimental Hematology, no 14, 1986, p 147-155
DSTKIM No
86-02919
CANDIS No
97615
Format(s):
Hardcopy;Originator's fiche received by DSIS

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