LIPOSOMES: A NEW GENERATION OF DRUG AND VACCINE CARRIERS

Authors
  1. Shek, P.N.
  2. Barber, R.F.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Liposomes recently have been extensively studied for their use as carriers in the delivery of drugs, antigens, hormones, enzymes and other biologicals. They work by protecting various encapsulated, biologically-active materials from immediate dilution or degradation in vivo. This promotes the delivery of entrapped drugs to the target organ by preventing premature release. Improved opacification of the liver and spleen on computed tomographic images has been effected in animals by IV administration of radiographic contrast agents when entrapped within liposomes. The effective targeting of liposomes to a selective site within the body depends on several factors; these include the biochemical composition, physical size, and the surface-associated ligands of liposomes used.
Report Number
DCIEM-86-P-12 — Research Paper
Date of publication
15 Apr 1986
Number of Pages
10
Reprinted from
Modern Medicine, 1986
DSTKIM No
86-02951
CANDIS No
97647
Format(s):
Hardcopy;Originator's fiche received by DSIS

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