A STUDY OF THE IMMUNOCHEMISTRY AND BIOPATHOLOGY OF STAPHYLOCOCCAL ENTEROTOXINS

Authors
  1. Micusan, V.V.
Corporate Authors
Defence Research Establishment Suffield, Ralston ALTA (CAN);Institut Armand Frappier, Laval QUE (CAN)
Abstract
Staphylococcus aureus strains produce a number of extra-cellular proteins, among them, a group of enterotoxins responsible for staphylococcal food poisoning and many of post-surgery infections. During the present contract, we have established new conditions for culturing S. aureus strains to produce enterotoxins. Antisera against several toxins (A,B,C and TSST-1) has been produced in rabbits and the possibility of producing monoclonal antibodies against the enterotoxins was explored. An enzyme-linked immunoassay (ELISA) was developed and used for an epidemiological study on the occurrence of anti-enterotoxins antibodies among civilian and military populations. The lack of a suitable animal model rendered difficult the study of the relationship between routes of administration and the pathology of the enterotoxins. TRUNCATED
Report Number
DRES-CR-18/86 — Contract Report (Final)
Date of publication
15 Mar 1986
Number of Pages
70
DSTKIM No
86-02957
CANDIS No
97653
Format(s):
Hardcopy;Originator's fiche received by DSIS

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