COLD TOLERANCE: AMINOPHYLLINE AND SUBSTRATES

Authors
  1. Wang, L.C.H.
  2. Man, S.F.P.
  3. Belcastro, A.N.
Corporate Authors
Alberta Univ, Edmonton ALTA (CAN);Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
The purpose of the study was to evaluate the effects of varying doses of aminophylline ingestion on thermogenesis during cold air exposure in human subjects. Ten males were exposed on 4 occasions to an ambient temperature which was individually tailored to induce a fall of rectal temperature of 1 to 1.5 C within a three hour period. Subjects ingested either corn starch (placebo), 125, 250, or 375 mg of theophylline immediately prior to cold exposure together with a standard nutrient mixture. During cold exposure the subject, dressed only in shorts, exercised intermittently at 50% maximum aerobic power with a 10 min/20 min exercise/rest ratio. Venous blood was sampled throughout the exposure. Heat production was calculated based on simultaneous and continuous measurements of oxygen consumption and carbon dioxide production. Results: The results showed that there is a dose-dependent increase in cold tolerance with oral theophylline. TRUNCATED
Date of publication
15 Jul 1986
Number of Pages
57
DSTKIM No
86-03373
CANDIS No
98061
Format(s):
Hardcopy;Originator's fiche received by DSIS

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