EFFECT OF ALTERATIONS IN METABOLIC RATE ON THE DURATION OF TOLERANCE IN NEONATALLY INJECTED ANIMALS

Authors
  1. St Rose, J.E.M.
  2. Murray, G.W.
  3. Howe, S.A.
Corporate Authors
Defence and Civil Inst of Environmental Medicine, Downsview ONT (CAN)
Abstract
Exposure to low environmental temperature caused a decrease in the half-life of human albumin (HA) in rabbits injected with 20 mg HA at birth, and a twofold increase in the proportion of animals which lost their tolerance by 150 days of age. Administration of thyroxin produced an even greater effect with respect to tolerance loss. Similar mechanism may be involved in the effects of cold exposure and thyroxin administration on tolerance duration. One possible mechanism is that the duration of tolerance is dependent upon the metabolic half-life of the tolerance-inducing antigen. An alternative mechanism could be a cold- or thyroxin-induced enhancement of the recruitment of immunologically competent cells from an undifferentiated population of stem cells.
Report Number
PUB-75-X-2 —
Date of publication
01 Jan 1976
Number of Pages
5
Reprinted from
International Archives of Allergy and Applied Immunology, vol 52, no 1, 1976, p 183-187
DSTKIM No
77-02449
CANDIS No
99202
Format(s):
Hardcopy;Originator's fiche received by DSIS

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