MODIFICATION OF SURVIVAL OF GAMMA IRRADIATED MICE BY ADENOSINE NUCLEOTIDES

Authors
  1. Grant, G.A.
  2. Barlow, J.A.
  3. Leach, K.E.
Corporate Authors
Defence Research Establishment Ottawa, Ottawa ONT (CAN)
Abstract
The administration prior to irradiation of adenosine triphosphate (ATP) or other adenosine nucleotides, singly or in combination, increased the radioresistance of mice. Post-irradiation treatment with the adenosine nucleotides had no effect on the survival of the irradiated mice. Dose reduction factors of 2.32 could be obtained by pretreatment of mice with the following combination of protective agents: S-2(4-aminobutylamino)ethyl phosphorothioic acid (WR 2822), cysteamine (MEA) and ATP. Since cyclic AMP levels were unchanged in the spleen or gut by administration of cysteamine and other protectors it is unlikely that the increase in protection was due to changes in cyclic AMP levels. The calcium salt of ATP provided a higher level of protection than the ATP alone, indicating that the protective mechanism of ATP is probably not related to anoxia.
Report Number
745 —
Date of publication
01 Jan 1976
Number of Pages
7
Reprinted from
Strahlentherapie no 152, no 3, 1976, p 285-291
DSTKIM No
77-02691
CANDIS No
99443
Format(s):
Hardcopy

Permanent link

Document 1 of 1

Date modified: